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In dieser Ausgabe:

Thyroglobulin Antibodies as a Prognostic Factor in Papillary Thyroid Carcinoma Patients with Indeterminate Response After Initial Therapy

The clinical outcome of papillary thyroid carcinoma (PTC) patients with an indeterminate response after initial therapy is reported to be intermediate, between incomplete and excellent responses. This study evaluated the outcomes of PTC patients with indeterminate response after initial therapy. It was further determined whether the indeterminate findings predicted outcomes more precisely. Patients were further classified into 3 groups based on risk of structural persistence/recurrence:Tg group:...

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Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Premenopausal Women with Metabolic Syndrome

It is suggested that estrogen protects premenopausal women against non-alcoholic fatty liver disease. From another perspective, the relation between metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) is bidirectional. Role of insulin resistance (IR) in NAFLD continues to be a matter of debate. The present study aimed to assess the relation between IR and NAFLD in premenopausal women with MetS. The study included 51 premenopausal women with MetS. In addition, there were 40 ag...

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Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population

There is a paucity of data on the relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and cardiometabolic biomarkers in the Chinese population. To comprehensively and quantitatively examine the association of 25(OH)D and cardiometabolic traits, we conducted a cross-sectional study in the Chinese rural population. Serum 25(OH)D and eight cardiometabolic biomarkers were measured in 1714 individuals from Henan province, China. Scatter plot was used to visualize the distribution and c...

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Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme of the mevalonate pathway, which generates cholesterol and non-sterol compounds such as isoprenoid, which are involved in key steps of tumorigenesis such as cell growth and proliferation. Our aim was to evaluate the role of the mevalonate pathway in adrenocortical tumors (ACTs). Expression pattern ofHMGCR,FDFT1,LDLR,SCARB1,StAR,TSPO,CYP11A1,CYP11B1,CYP17A1,CYP21A1, andHSD3B1genes,involved in the mevalonate pathwa...

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Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice

Resistin was identified as a link between obesity and insulin resistance and is associated with many diseases in mice. Deciphering the related development and molecular mechanism is necessary for the treatment of these diseases. Previous studies have revealed that increased resistin levels are correlated with lipid accumulation and play a role in non-alcoholic fatty liver disease (NAFLD) development. However, the exact mechanisms underlying these processes remain unclear. To further clarify whet...

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Does SGLT2 Inhibition Affect Sympathetic Nerve Activity in Type 2 Diabetes?

SGLT2 inhibitors increase renal glucose excretion and thus decrease both fasting and postprandial plasma glucose levels. The effects of SGLT2 inhibition outweigh those on glycemic control and are also associated with the induction of hemodynamic changes that improve cardiovascular and renal function in people with type 2 diabetes. The exact mechanisms have not yet been completely clarified. This review is focused on the potential relationship between SGLT2 inhibition and sympathetic nerve activi...

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Obesity is Associated with Poor Covid-19 Outcomes: A Systematic Review and Meta-Analysis

Our aim was to assess the association between obesity and the risk of unfavourable outcomes (composite of severe disease and mortality) in inpatients with COVID-19. We conducted a systematic search of databases between December 2019 and 28th June 2020. Studies were included if they reported or allowed estimation of an odds ratio (OR) for unfavourable outcome in obese compared to non-obese patients hospitalised for COVID-19. Twenty cohort studies of 28 355 hospitalised patients with COVID-19 infe...

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DOI: 10.1055/s-011-50230

Hormone and Metabolic Research

Ausgabe 02 · March 2021

Review

85
Hoong, Caroline Wei Shan; Hussain, Ikram; Aravamudan, Veeraraghavan Meyyur; Phyu, Ei Ei; Lin, Jaime Hui Xian; Koh, Huilin : Obesity is Associated with Poor Covid-19 Outcomes: A Systematic Review and Meta-Analysis

Endocrine Care

94
Landenberger, Giullia Menuci Chianca; de Souza Salerno, Marianna Lins; Golbert, Lenara; de Souza Meyer, Erika Laurini : Thyroglobulin Antibodies as a Prognostic Factor in Papillary Thyroid Carcinoma Patients with Indeterminate Response After Initial Therapy
100
El-Sehrawy, Amr Ali; State, Omnia; Elzehery, Rasha Rizk; Mohamed, Ahmed Salem : Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Premenopausal Women with Metabolic Syndrome
105
Zhang, Dongdong; Cheng, Cheng; Wang, Yan; Xue, Yuan; Liu, Yiming; Li, Wenjie; Li, Xing : Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population
112
Wang, Benjing; Zhang, Qin; Wang, Qi; Ma, Jun; Cao, Xiaoju; Chen, Yaping; Pan, Yuhong; Li, Hong; Xiang, Jingjing; Wang, Ting : Investigating the Metabolic Model in Preterm Neonates by Tandem Mass Spectrometry: A Cohort Study

Endocrine Research

124
Lima-Valassi, Helena Panteliou; Lerario, Antonio Marcondes; Montenegro, Luciana Ribeiro; Fragoso, Maria Candida Barisson Villares; Almeida, Madson Queiroz; Mendonca, Berenice Bilharinho; Lin, Chin Jia : Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis
132
Wen, Fengyun; Shi, Zhuoyan; Liu, Xiaoping; Tan, Yuguang; Wei, Lan; Zhu, Xuemin; Zhang, Hui; Zhu, Xiaohuan; Meng, Xiangmiao; Ji, Weixia; Yang, Mengting; Lu, Zhaoxuan : Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice

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