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DOI 10.1055/s-00000034

Klinische Pädiatrie

In dieser Ausgabe:

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Impact of COVID-19 Related Restrictions on Infections in Children with Cancer or after Hematopoietic SCT

Background Infections are a major concern for immunocompromised children. We investigated whether non-pharmaceutical interventions (NPIs) implemented in the general population during the coronavirus disease 2019 (COVID-19) pandemic in Germany had an impact on frequency, type and severity of infections in these patients.

Patients and methods We analyzed all admissions to the clinic of pediatric hematology, oncology and stem cell transplantation (SCT) with (suspected) infection or fever of unknown or...

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Miliary Pulmonary Nodules in a 9-Year-Old Child – The Search for the Origin and its Consequence for Treatment

Thyroid cancer is the most common endocrine malignancy, although representing less than 1% of all human tumors. Differentiated thyroid carcinoma (DTC) includes the papillary and follicular histotypes and their variants [Pacini F. et al., The Medical clinics of North America (2012), 2: 369–383]. Papillary thyroid carcinoma (PTC) is the most common type (approx. 80%) and has a good prognosis, leading to a survival rate of 93% at 10 years [Erden E. et al., Case reports in medicine (2013)]. Although...

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Erratum

Correction: Impact of COVID-19 Related Restrictions on Infections in Children with Cancer or after Hematopoietic SCT

Leitlinie

Leitlinie Myokarditis der Deutschen Gesellschaft für Pädiatrische Kardiologie

Originalarbeit

Kinder und Jugendliche mit intrakraniellem Ependymom – Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie

Anerkannter Grad der Behinderung (GdB) im Langzeitverlauf nach Kraniopharyngeom im Kindes- und Jugendalter

Screening zur Einschätzung des psychosozialen Nachsorgebedarfs in der pädiatrischen Onkologie (NPO-11) für Selbst- und Elternbericht

Original Article

Impact of COVID-19 Related Restrictions on Infections in Children with Cancer or after Hematopoietic SCT

Pictorial Essay

Isolated extradural sacrococcygeal ependymoma mimicking teratoma in a 5-year-old boy

Short Communication

Miliary Pulmonary Nodules in a 9-Year-Old Child – The Search for the Origin and its Consequence for Treatment

Abstracts

CD19-Targeted immunotherapies for Treatment of Pediatric t(8;21) Leukemia

Expression of retinoic acid receptor gamma is modulated by miR-30a

A novel combinatorial therapy improves the outcome of t(4;11) infant pro-B-ALL through the precise induction of HDAC7 biomarker

Optimizing CRISPR/Cas9 technologies to develop disease model systems

CSF1R as a marker of lineage plasticity in MLL-AF9 infant leukaemia

Transcription vulnerabilities profiling through combinatorial CRISPR screens for personalized pediatric cancer therapy

Deciphering the role of KANSL1 mutations in the development of Myeloid Leukemia in children with Down Syndrome (ML-DS)

AML-derived small EVs containing YBX1 influences mesenchymal stromal cells differentiation in the bone marrow niche

Exopolyphosphatase Activity of PRUNE Regulates Adaptive Starvation Responses in Cancer Cells

PROM1/CD133 expression identifies highly proliferative MLL-AF4+ blasts and correlates with a stem-like gene signature

Single cell RNAseq uncovering the role of RUNX1/ETO in the leukemic niche signaling

SarcDBase: a tool for detection of genetic alterations in sarcoma

Leukaemia in the CNS niche regulates PI3K/Akt signalling via upregulation of miR-93 in MLL-AF4+ infant leukaemia

Blocking TIM3:Galectin-9 pathway enhances in vivo CAR19T cell function

Characterizing the role of BCL-2 family members as targets for anti-cancer therapy in T-ALL

Radiosensitivity in pediatric solid tumors

From bench to bedside – Establishing PRMT5 inhibitors in the treatment of Glioblastoma multiforme

Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow

Comparison of CD28- and 4-1BB-based CLEC12A-CAR-natural killer cells against acute myleoid leukemia

Decoding Epigenetic Landscape in Pediatric Leukemia through Multi-Omics Integration

Single cell multiomic analysis of clonal and transcriptional programs of CD19 CAR T cells in the immunotherapy response

The transcriptional landscape and the immune microenvironment of the testicular niche in pediatric ALL

Impact of posttranscriptional regulations of MLL-AF4 and its target Genes in pro B-ALL

Enhancing TRAIL-mediated killing of ErbB2-CAR-NK-92 (NK-92/5.28.z) with bortezomib

Restoration of miRNA-193b-3p function is a potent therapeutic option in acute myeloid leukemias

The role of the DACH family of nuclear proteins in MLL-AF4-associated infant leukaemia

Methyltransferase-dependent and -independent functions of EZH2 in H3K27M-mutant diffuse intrinsic pontine gliomas

Spatial analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in pediatric AML

Identification of the genetic mechanisms linked to the occurrence of H3.3K27M-mutation in pediatric DIPG

A screening of donated chemical probes to identify novel therapeutic options for childhood AML

Medulloblastoma EVs influence TGF-beta/SMAD1 signaling in mesenchymal stem cell

Effective targeting of Wnt Signaling in B Cell Precursor Acute Lymphoblastic Leukemia

Wnt/STOP activation drives temporally dynamic ribosomal biogenesis in drug resistant leukemia cells

IKZF1plusplus? Investigating the genetic complexity of IKZF1 deleted B-cell acute lymphoblastic leukemia

Choosing the right effector cell for ErbB2-CAR-engineered immunotherapy in rhabdomyosarcoma – CAR-T vs CAR-CIK

Early subclinical CNS manifestation in B-cell acute lymphoblastic leukemia modelled in vivo

Synergistic anti-leukemia activity of the dual mTOR/PI3K inhibitor NVP-BEZ235 with the BCL-2 inhibitor venetoclax

An innovative tailored CAR T cell-redirecting immunotherapy for the treatment of metastatic and refractory Ewing Sarcoma

Menin Inhibition In Hox/Meis1 Dysregulated Amls

Examination of RNA exosome mediated RNA decay as context-dependent cellular vulnerability

NK cell immunotherapy against chemotherapy-resistant rhabdomyosarcoma

Understanding Nfe2l2/Keap1-Mediated Drug Resistance In Hepatoblastoma

NG2 and VLA-4 are involved in the invasion and migration of MLLr B-cell Acute Lymphoblastic Leukemia

TP53 separation-of-function mutations through promoter swapping in osteosarcoma

Inhibition of autophagy as therapeutic approach for pediatric diffuse intrinsic pontine glioma

Targeting the fetal transcriptional landscape of pediatric AML

Identifying Gene Targets for Drug repurposing to prevent Cancer in children with a premalignant state

RAS pathway mutations drive oncofetal reprogramming in hematopoietic stem cells

Comprehensive molecular and clinical characterization of DUX4-rearranged B-acute lymphoblastic leukemia

Targeting the non-coding ands stem cell signature in childhood acute myeloid leukemia

Identification of novel fusion transcripts in Acute Myeloid Leukemia

Minimal invasive detection of circulating biomarkers in pediatric brain tumor patients using liquid biopsy

Application of VDJ recombination events probability for γδ T-cells in MRD monitoring

A novel fratricide-resistant CAR-T cell immunotherapy for T-ALL

Rituximab clearance in pediatric patients with mature aggressive B-cell Non-Hodgkin Lymphoma

Oncogenic mechanisms of fusion proteins in pediatric acute myeloid leukemia

Exploring the novel function of mutant NPM1 on chromatin

Identification and functional characterization of CTCF-bound noncoding RNA loci in acute myeloid leukemia.

Functional Characterization of potential diagnostic targets in Burkitt-NHL

Inhibition of the ”don’t eat me signal” CD47 to prevent relapse in juvenile myelomonocytic leukemia

Identification of Functional Defects Leading to Bone Marrow Failure in GATA2 Deficiency

Identification of cell-extrinsic pro-survival factors in JMML

Comparison of armored NK cells equipped with soluble and membrane-bound IL-15 variants for improved functionality

Association and interactions of the RIO kinases in the context of Diamond-Blackfan anemia

Investigating and modulating leukemia initiating cells to reduce risk of post-transplant relapse in JMML

Acute Myeloid Leukemia initiating cells: identification of new therapeutic targets to avoid relapse

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