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DOI 10.1055/s-00000034

Klinische Pädiatrie

In dieser Ausgabe:

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Fear of Progression in Parents of Children with Cancer: Results of An Online Expert Survey in Pediatric Oncology

Background Fear of Progression (FoP) is a commonly reported psychological strain in parents of children with cancer. This expert survey investigates how professionals in pediatric oncology estimate the burden and consequences of FoP in parents and how they assess and treat parental FoP.

Method N=77 professionals in pediatric oncology (members and associates of the Psychosocial Association in Paediatric Oncology and Haematology, PSAPOH) were examined in an online survey with a self-developed questio...

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Duodenocolonic Fistula As A Rare Complication of Intestinal Burkitt Lymphoma in a Three-Year-Old Boy

Background Burkitt lymphoma (BL) in children often presents with abdominal localization. Intestinal perforations have been described mainly during treatment. We report on a three-year-old patient with abdominal BL who was diagnosed with a duodenocolonic fistula.

Case report A three-year-old boy presented with diarrhea, crampy abdominal pain, and a four-week history of loss of appetite and weight. Ultrasound and MRI detected a colonic tumor forming a duodenocolonic fistula which was verified by gast...

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Editorial

Übersicht

Empfehlungen zur Diagnostik und Therapie bei krebskranken Kindern mit Fieber und Neutropenie – Vergleich zweier aktueller Leitlinien

Fertilitätserhalt bei präpubertären und pubertären Kindern und Jugendlichen

Original Article

Fear of Progression in Parents of Children with Cancer: Results of An Online Expert Survey in Pediatric Oncology

Duodenocolonic Fistula As A Rare Complication of Intestinal Burkitt Lymphoma in a Three-Year-Old Boy

A Comparison of GFR Estimation Formulae in Pediatric Oncology

Diagnostic and Treatment Recommendation

Beckwith-Wiedemann-Syndrom (BWS): Aktueller Stand der Diagnostik und des klinischen Managements

Short Communication

Hypereosinophilia as Presenting Symptom of a Pre-B-ALL

Nachruf

Nachruf Prof. Dr. med Hermann Mildenberger

Top 1 Acute and chronic leukaemias

Comparison of NGS and RT-PCR approaches for MRD monitoring in acute lymphoblastic leukemia

Human-zebrafish xenograft platform to individualise therapy for acute lymphoblastic leukaemia patients (ALL-ZeFiX)

Identification of glycolytic pathway as RUNX1/ETO-dependent for propagation and survival

Evaluation of dsDNA from extracellular vesicles (EVs) as biomarker in pediatric AML

Biomarker potential of mRNA in extracellular vesicles in pediatric AML

Deciphering the genetically interactive network of the DLK1-DIO3 ncRNA locus in the hematopoietic system and pediatric acute megakaryoblastic leukemia

Modelling the progression of a preleukemic stage to overt leukemia in children with Down syndrome

In vitro and in vivo genome wide CRISPR screening under drug treatment in T-ALL

CRISPRi screening to identify functional long noncoding RNAs in pediatric acute myeloid leukemia

Methotrexate-associated toxicity during therapy of acute lymphoblastic leukemia in children with Down syndrome

Cooperativity between miR-125b and Gata1 s in the pathogenesis of Down syndrome-associated myeloid leukemia

Patient-derived xenografts for pre-clinical drug development in AML

Redeployed drug inducing MLL fusion degradation

Functional and molecular characterization of oncogenic dependencies on chromosome 21 in Down syndrome-associated myeloid leukemia

Chemokine receptor expression in central nervous system (CNS) positive childhood acute lymphoblastic leukemia

Investigating novel drug combinations against patient-derived xenografts of acute lymphoblastic leukaemia

Therapeutic targeting of the leukaemic fusion gene RUNX1/ETO

Top 3 Solid tumors

Comparative integrative analysis of primary and relapsed atypical teratoid/rhabdoid tumors (AT/RTs)

Circular RNAs in Neuroblastoma

Preclinical evaluation of BET-inhibition as monotherapy and combination therapy in MYC-driven neuroblastoma

Exosomal (exo) dsDNA as a diagnostic and prognostic tool in pediatric solid tumours

Response and Resistance of ALK-mutated Neuroblastoma Cells to Ceritinib

Cell free circulating tumor DNA represents a serum marker in Ewing sarcoma patients – update of the EFACT study

PIK3CA mutations significantly enhance the growth of Shh medulloblastoma

SP8 promotes an aggressive phenotype of hepatoblastoma cells

The role of BCORL1 in hepatoblastoma

Loss of SMARCA4 in neural progenitor cells causes rosette-forming proliferative lesions in the developing mouse brain

Top 5 Cell biology and mechanisms of disease

Defining the role of Id2 in human erythropoiesis

The interplay between IKZF1 and COBL deletions in leukemia

Hippo-YAP pathway activation favors neuroblastoma progression

CD79a impacts central nervous system (CNS) infiltration of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL)

Intra- and extra-cranial Malignant Rhabdoid Tumours share common location-independent clinical and molecular disease characteristics.

Chromosome segregation defects as early underlying pathogenic mechanism in hyperdiploid childhood B-cell acute lymphoblastic leukaemia

SMARCB1-Dependencies in Malignant Rhabdoid Tumours: A strategy for Pre-Clinical Therapeutic Target Identification in the Absence of Actionable Mutations

Differences in stroma cell signaling after contact to acute lymphoblastic leukemia B-cells derived from adult and pediatric patients

Response and Resistance of ALK-mutated Neuroblastoma Cells to Ceritinib

The oncogenic transcription factor RUNX1/ETO corrupts the cell cycle to drive leukaemic transformation

Top 6 Immuno-, molecular and cell therapy

The non functional-P2X7-receptor in pediatric solid tumors

Adoptive Cellular Immunotherapy using CD1a CART-cells for Treatment of Cortical Pediatric T-Cell Acute Lymphoblastic Leukemia

Methadone potentiates the cytostatic effect in Rhabdomyosarcoma and malignant Rhabdoid Tumors

Targeting CD38 in T-ALL using a novel Fc-engineered antibody

Top 7 Novel approaches and applications

High-throughput sequencing of clonal TCR alpha genes rearrangements in pediatric T-lineage acute lymphoblastic leukemia

Monitoring of minimal residual disease in MYCN-amplified neuroblastoma by chromosomal breakpoint recognition

Comparison of differential ultracentrifugation (DC) and size exclusion chromatography (SEC) based exosome isolation methods

Deciphering the oncogenic network of PRC-2 loss guided leukemogenesis

Morphorheological changes of neutrophils in patients with neutropenic fever

DCAL goes NGS: Unveiling the complexity of MLL rearrangements using targeted-DNA sequencing

A target-specific reporter system to enrich cells with CRISPR/Cas9-induced knockout

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Buchtipps Pädiatrie

Kinderkardiologie

Nikolaus A. Haas, Ulrich KleideiterKinderkardiologie

Klinik und Praxis der Herzerkrankungen bei Kindern, Jugendlichen und jungen Erwa

EUR [D] 79,99Zum Warenkorb hinzufügenInkl. gesetzl. MwSt.

Differenzialdiagnosen in der Kinder- und Jugendmedizin

Robert PloierDifferenzialdiagnosen in der Kinder- und Jugendmedizin

EUR [D] 89,99Zum Warenkorb hinzufügenInkl. gesetzl. MwSt.

Praktische Pneumologie in der Pädiatrie - Diagnostik

Matthias Griese, Thomas Nicolai, Robert Dalla Pozza, Christoph Döhlemann, Richard de la ChauxPraktische Pneumologie in der Pädiatrie - Diagnostik

Rationale Differenzialdiagnostik

EUR [D] 49,99Zum Warenkorb hinzufügenInkl. gesetzl. MwSt.

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