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DOI 10.1055/s-00000034

Klinische Pädiatrie

In dieser Ausgabe:

High Dose Chemotherapy with Autologous Stem Cell Transplantation in Hepatoblastoma does not Improve Outcome. Results of the GPOH Study HB99

Introduction The purpose of the German HB99 trial (1999–2008) for hepatoblastoma (HB), was primarily to analyse the effect of high dose (HD) chemotherapy with carboplatin/etoposide (CE) in high risk (HR) patients with extended tumors, vessel involvement, extrahepatic tumor or distant metastases. In standard risk (SR) patients the effect of treatment reduction was analysed.

Methods HR patients received 2 cycles CE at conventional dose, followed by 2 at HD with subsequent autologous stem cell transpl...

Prediction of ECMO and Mortality in Neonates with Congenital Diaphragmatic Hernia Using the SNAP-II Score

Background The mortality of neonates with congenital diaphragmatic hernia (CDH) ranges between 20 and 40% even in specialized high-volume centers. The Score for Neonatal Acute Physiology-II (SNAP-II Score) could facilitate the decision about supportive therapies in CDH newborns.

Methods The SNAP-II score consists of the variables arterial blood pressure, pH, PaO₂:FiO₂, body temperature, diuresis, and seizure activity and was calculated at an age of 12 h.

Results 101 CDH newborns treated in our instit...