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DOI 10.1055/s-00000034

Klinische Pädiatrie

In dieser Ausgabe:

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Revaccination in Children Undergoing Autologous Hematopoietic Stem Cell Transplantation: Results of a Survey in Germany, Austria and Switzerland

Background Due to the potential loss of protective antibody titers after autologous hematopoietic stem cell transplantation (HSCT), revaccination is important. The aim of the study was to evaluate the current strategies in Germany, Austria and Switzerland for revaccination of children after autologous HSCT.

Methods An internet-based survey was performed, and results were analyzed in a descriptive way.

Results Twenty-seven out of 31 centers (87%) centers responded, and all centers administer revaccina...

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Limited Walking Abilities and Impaired Ankle Dorsiflexion Function in Children After Intense Cancer Treatment

Background With improved survival rates in pediatric oncology, the detection of adverse side- and late-effects is gaining increased interest. This cross-sectional study investigated walking abilities and ankle dorsiflexion function in children with cancer.

Patients Study participants included 16 children with various cancers (4–20 years, patient group) after completion of the intense treatment and 16 age- and gender-matched healthy peers (comparison group).

Method Walking speed (10-meter-walking-test...

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Diagnostic and Treatment Recommendation

SIOP-E-BTG and GPOH Guidelines for Diagnosis and Treatment of Children and Adolescents with Low Grade Glioma

Original Article

Revaccination in Children Undergoing Autologous Hematopoietic Stem Cell Transplantation: Results of a Survey in Germany, Austria and Switzerland

Limited Walking Abilities and Impaired Ankle Dorsiflexion Function in Children After Intense Cancer Treatment

Originalarbeit

Bewegungsförderung in der Pädiatrischen Onkologie – Strukturelle Voraussetzungen und Finanzierungsmöglichkeiten anhand des Leipziger Bewegungskonzepts

Abstracts

CD19 and CD22-directed biespecific CAR for B-cell Acute Lymphoblastic Leukemia

Chromosome structure and mitotic defects are major pathogenic mechanisms in hyperdiploid childhood B-ALL

CRISPR-mediated genome editing of t(4;11) in human prenatal and perinatal hematopoietic stem/progenitor cells

Evolutionary trajectories and cell-of-origin of TCF3-ZNF384&PTPN11 mutations in monozygotic twins with concordant B-ALL

Inactivation of Nsd1 impairs terminal erythroid maturation and induces erythroleukemia

WNT Medulloblastoma: More than just β-Catenin Mutations – Rare Genetic Features in the Focus

Giant cell glioblastoma does not represent a distinct entity but stratifies into different genetically defined entities

Machine learning algorithms for the automated classification of pediatric anemia

Large amplicon droplet digital PCR for DNA-based monitoring of pediatric chronic myeloid leukemia (CML)

Multiplex Droplet Digital PCR-based Targeted Enrichment NGS for identification of tumor markers in Ewing Sarcoma (EwS)

TRIM28 haploinsufficiency predisposes to Wilms tumor

Screening assay to identify potential Taspase1 inhibitors

Investigating HDACi and dnTaspase1 for the treatment of t(4;11) leukemic cells

Mutational and transcriptomic landscapes in hematopoietic cells of Fanconi anemia patients

Analyzing the effects of oncogenic SHP2 on apoptosis signaling during malignant transformation

Analyzing the therapeutic efficacy of navitoclax and MCL-1 inhibitors in juvenile myelomonyctic leukemia

Too little is too much: Leukemogenesis in the Gata2 syndrome

Low regulatory T-cells are associated with improved survival of neuroblastoma patients treated with anti-GD2 antibodies

Blockade of suppressive myeloid cells is effective against neuroblastoma

Identification of a new splice variant of the human transcription factor ONECUT2

Identification of GATA1 s interaction partners in Down syndrome-associated myeloid leukemia

Establishment of new therapeutic options for the treatment of Myeloid Leukemia in Down syndrome (ML-DS)

Deciphering the interactive network of the DLK1-DIO3 locus in hematopoiesis and pediatric acute megakaryoblastic leukemia

Therapeutic application of the tumour suppressive miR-193b in Acute Myeloid Leukaemia

Cooperativity between miR-125b and Gata1 s in the pathogenesis of Down syndrome-associated myeloid leukemia

CRISPRi screen to identify functional long noncoding RNAs in pediatric acute myeloid leukemia

Deciphering the role of lncRNAs in pediatric AML

Using Acute Promyelocytic Leukemia to study the H3.3 Histone chaperone system and its role in pediatric malignancies

Interrogating the Role of Chromatin Regulator BRD4 in the DNA Damage Response in Medulloblastoma

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Functional characterization of RUNX1 variants in the context of FPDMM

Functional analysis of class I HDAC inhibition in group 3 medulloblastoma to identify synergistic drug combinations

Mapping the single cell transcriptome reveals the cellular composition of ATRT subgroups

Stratification and prognosis of IGH-DUX4 positive acute lymphoblastic leukemia in children

FOS and FOSB are linked with CNS-infiltration and inferior prognosis in childhood T-cell acute lymphoblastic leukemia

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies

Epigenetics profiling for minimal residual disease in paediatric acute myeloid leukaemia

Targeting c-MYB in Acute Leukaemia through Drug Repositioning

Drug Repositioning in Infant Leukaemia

Tripartite motif-containing 71 (TRIM71) is a major factor of oncogenic activity in human hepatoblastoma

Inhibition of the polycomb repressive complex 1 (PRC1) as a therapeutic option in childhood liver tumors

Isolation and characterization of tumor-derived exosomes from a patient-derived xenograft mouse model of acute leukemia

Splicing factors of the SF3b complex PHF5A and SF3B1 regulate the DNA damage response in ALL

Dasatinib and Dexamethasone offer a novel therapeutic strategy for T-cell Acute Lymphoblastic Leukaemia

Genome-wide CRISPR screen in patient derived cells reveals the mechanism of ALL chemoresistance

Genomic characterisation of lineage switched MLL-rearranged leukemias

Downstream effect of CSF3R and RUNX1 mutations that underlie leukemic transformations in congenital neutropenia (CN)

CRISPR/Cas9 Gene-modification Platform of ELANE Mutations in iPSCs and HSPCs of Severe Congenital Neutropenia Patients

iPSC Model of Stepwise Leukemia Development in Congenital Neutropenia Reveals BAALC as a Key Mediator of Leukemogenesis

GADD45b plays an essential role in the G-CSF triggered granulocytic differentiation of human hematopoietic cells

NAMPT-mediated LMO2 deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

Tumour Necrosis Factor receptor (TNFR)-signalling dependent killing in T-cell acute lymphoblastic leukaemia (T-ALL)

Liquid biopsy in neuroblastoma: cfDNA analysis for sensitive follow-up monitoring and early relapse detection

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