A possible negative consequence of cancer treatment is the fertility impairment of young cancer survivors. However, most former patients express the wish to have biological children. Fertility-preserving measures are available and are – under certain circumstances – financed by health insurance. Separate information at the time of diagnosis and during follow-up care should be adapted to the individual risk and enable those affected to make a self-determined decision about cryopreservation of ger...

Die Langerhanszell Histiozytose (LCH) ist eine seltene neoplastische Erkrankung, die vor allem im Kindes- und Jugendalter auftritt. Die Erkrankung kann prinzipiell jedes Organ befallen, weswegen sehr unterschiedliche klinische Erscheinungsbilder möglich sind. Der klinische Verlauf der LCH reicht von einer Spontanheilung bis hin zu einem rasch progredienten tödlichen Verlauf. Die Ausbreitungsdiagnostik bestimmt das Vorgehen. Manche Patienten qualifizieren sich für eine watch-and-wait Strategie, w...

Fieber im Kindes- und Jugendalter ist ein häufiger Grund ärztlicher Konsultation. Die Ursache ist oft unklar und beinhaltet ein breites Spektrum an Differentialdiagnosen. Die Herausforderung besteht darin anhand von Anamnese, der klinischen Untersuchung und ggf. ergänzenden laborchemischen und apparativen Untersuchungen die Ätiologie zu klären, um eine adäquate Therapie einleiten zu können. Wie im vorliegenden Fall beschrieben, gelingt dies oft auch nur durch schrittweisen Ausschluss anderer in ...

Background The outcome of children with refractory or relapsed soft tissue sarcoma (STS) is extremely poor. Whereas larger clinical trials evaluated specific treatment modalities, real-life data on individual multimodal therapeutic strategies, given alone or in combination, are scarce.

Patients and Methods We retrospectively analyzed the clinical course of 18 pediatric patients with progression of or relapsed STS treated between 2008 and 2018 in our institution.

Results A total of 18 patients (median...

Background Sickle cell disease (SCD) is a group of hemoglobinopathies with a common point mutation causing the production of sickle cell hemoglobin (HbS). In high-throughput newborn screening (NBS) for SCD, a two-step procedure is suitable, in which qPCR first pre-selects relevant samples that are differentiated by a second method.

Methods Three NBS centers using qPCR-based primary screening for SCD performed a laboratory comparison. Methods using tandem MS or HPLC were used for differentiation.

Res...

Background Psychosocial guidelines and standards systematically describe stressors and resources in particularly challenging situations and hence serve as a basis for interventions to achieve defined psychosocial goals. Despite fundamental principles and guidelines for psychosocial methods, the quality of provided care varies considerably depending on setting, provision, and profession. The purpose of the present protocol is to illustrate the development and evaluation of the standardized psychol...