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Nuklearmedizin

DOI 10.1055/s-00034924

Nuklearmedizin

In dieser Ausgabe:

[ 68 Ga]Ga-DATA 5m .SA.FAPi PET/CT: Specific Tracer-uptake in Focal Nodular Hyperplasia and potential Role in Liver Tumor Imaging

Fibroblast activating protein (FAP) is a membrane bound serine protease up-regulated in activated fibroblasts. These are essential for tissue remodeling in wound healing, chronic inflammation as well as in carcinoma associated fibroblasts (CAF) in several types of cancer1258911. Subject of recent developments are new68Ga-labelled PET tracers that operate as FAP-specific enzyme inhibitors (FAPi). The inhibitor is a small molecule based on a 4.4-difluoroproline-quinoline motif with a carbonitrile ...

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Multimodal Imaging of Schwannoma in Hepatic Hilar Region

A schwannoma is a benign mesenchymal tumor, which originates from Schwann cells in the nerve sheath. Most of the schwannomas are located in the cranial or spinal canal cavity, while some may be located in the hepatic hilar region though this is extremely rare. Herein, we present a case of an older woman with two schwannomas in the hepatic hilar region, who then had preoperative multimodal imaging, in which18F-FDG PET/CT scans showed a markedly increased18F-FDG uptake, mimicking that of malignant...

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Response assessment of somatostatin receptor targeted radioligand therapies for progressive intracranial meningioma

Background  In somatostatin receptor (SSTR) expressing progressive meningioma, peptide receptor radionuclide therapy (PRRT) has shown effect in small clinical series. However, standardized treatment and response assessment protocols are lacking. We present our experience on PPRT with177Lu-DOTATATE in progressive meningioma with a special emphasis on state-of-the-art response assessment.

Methods  Retrospective analysis on PRRT with177Lu-DOTATATE from 2015 to 2019. Pre- and post-therapy imaging was p...

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Impact of FDG-PET on therapy management and outcome of differentiated thyroid carcinoma patients with elevated thyroglobulin despite negative iodine scintigraphy

Aim  The objective of this study was to assess the impact of implementing FDG-PET imaging in treatment algorithms for differentiated thyroid cancer with suspected recurrence. Primary end points were overall, event-free and disease-specific survival. Secondary end points were therapies, disease control and the sensitivity and specificity of PET imaging.

Methods  194 patients with DTC treated at our center from 1996 to 2014 following thyroidectomy and routine131I ablation with no remaining131I uptake...

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Estimation of [ 177 Lu]PSMA-617 tumor uptake based on voxel-wise 3D Monte Carlo tumor dosimetry in patients with metastasized castration resistant prostate cancer

Objective  Patients with advanced prostate cancer are suitable candidates for [177Lu]PSMA-617 therapy. Integrated SPECT/CT systems have the potential to improve the accuracy of patient-specific tumor dosimetry. We present a novel patient-specific Monte Carlo based voxel-wise dosimetry approach to determine organ and total tumor doses (TTD).

Methods  13 patients with histologically confirmed metastasized castration-resistant prostate cancer were treated with a total of 18 cycles of [177Lu]PSMA-617 t...

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