Addition of Grignard Reagents to Alkenyl-Substituted Aromatic NHCs

Currently the vast majority of chiral pharmaceuticals are produced as single enantiomers, but the syntheses often rely on non-catalytic stoichiometric methods and the use of chiral separation techniques. The efficient catalytic synthesis of pharmaceutically important chiral heteroarenes is a core objective of modern chemistry. The group of Professor Syuzanna Harutyunyan at the Stratingh Institute for Chemistry, University of Groningen (The Netherlands) investigated the hypothesis that catalytic asymmetric C–C bond formation using conjugate addition of organometallics to conjugated alkenyl-heteroarenes would be a straightforward approach for constructing single enantiomers of chiral heteroarenes.

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