Aryltrimethylgermanes for the Arylation of Amines and Amides
Palladium-Catalyzed N-Arylation of Amines and Amides with Aryltrimethylgermanes: Q. Zhang, C. Liu, J. Shi, Q. Xu, L. Jin, C. Zhao, T. Zhang
Synlett 2016, 27, DOI: 10.1055/s-0035-1562104
Organogermane compounds could be valuable and user-friendly alternatives to the corresponding organoboron – which can be difficult to purify – and organotin or organolead derivatives – which are also often toxic – for a number of reactions catalyzed by metal catalysts. Recently, Professor Qiang Zhang and co-workers from the Shaanxi University of Technology (P. R. of China) reported a useful Pd-catalyzed arylation of amines and amides using aryltrimethylgermane compounds.
Professor Zhang said: “Primary/secondary amines or even amides could be smoothly arylated through palladium-catalyzed C–N bond formation reaction employing aryltrimethylgermanes as new arylating reagents in moderate to excellent yields.”