Bunte Salts as Thiolating Reagents for Alkenes
Sen Lin describes the synthesis of β-acetamido sulfides using Bunte salts as thiolating reagents.
NaI-Mediated Acetamidosulfenylation of Alkenes with Bunte Salts as
Synlett 2017, 28, DOI: 10.1055/s-0036-1588144
The β-acetamido sulfide motif is present in a number of biologically active and natural compounds such as lactacystin and others. However, its synthesis is not an easy task to accomplish for the synthetic chemist, especially when it comes to performing the synthesis of β-acetamido sulfides in a user-friendly and efficient manner. Recently, the group of Professor Sen Lin from the Nanchang University (P.R. of China) has reported a novel strategy for readily transforming alkenes into the title compounds using Bunte salts (RS-SO3Na) in very good yields (up to 87%).
Bunte salts as thiolating reagents for alkenesvergrößern
Professor Lin said:
“In our work, a direct and efficient method for the