Catalytic N-Radical Cascade Reaction of Hydrazones

N-Centered radical reactions have been established as one of the most powerful and versatile methods for C–N bond formation towards the assembly of valuable and diversely functionalized N-containing compounds. Typically, the generation of reactive N-radical intermediates has relied mainly on reductive scission of the relatively weak N–O, N–N or N–X (X = Br, I) bonds by high-energy UV irradiation or radical initiators. In contrast, the direct catalytic conversion of ubiquitous N–H bonds to N-centered radicals is an economic and attractive, but challenging, strategy for synthetic chemists). Recently, Professor Jia-Rong Chen’s group at the Central China Normal University (Wuhan, P. R. of China) has been interested in visible-light photoredox-controlled reactions of N-radicals. Employing this strategy, they developed a novel visible-light photocatalytic N-radical cascade reaction of β,γ-unsaturated hydrazones by combining oxidative deprotonation electron transfer (ODET) and hydrogen-atom transfer (HAT), which provided efficient access to various structurally diverse 1,6-dihydropyridazines.

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