[3+2] Cycloaddition of Azomethine Ylides
Haifei Wang describes the Ag(I)-catalyzed [3+2] cycloaddition of azomethine ylides.
Synlett 2017, 28, DOI: 10.1055/s-0036-1588137
The synthesis of five-membered nitrogen-containing heterocycles, in particular highly substituted pyrrolidines, has been the focus of much attention, as these structural motifs are widely present in many natural alkaloids and pharmaceutically useful agents. The [3+2] cycloaddition reaction of azomethine ylides to electron-deficient alkenes is one of the most useful tools for constructing highly substituted pyrrolidines. The group of Professor Haifei Wang at Hunan University of Technology (P. R. of China) has recently reported a new methodology for the stereocontrolled synthesis of extensively functionalized pyrrolidines.
Professor Wang said:
“In the paper, our group reported that the chiral L-