Mechanistic Insight on the Bromocycloetherification of Alkenes
Scott Denmark gives insight into the mechanism of the bromocycloetherification of alkenes.
Investigating the Enantiodetermining Step of a Chiral Lewis Base Catalyzed Bromocycloetherification of Privileged Alkenes: D. Böse, S. E. Denmark
Synlett 2018, DOI: 10.1055/s-0036-1590951
Enantioselective halofunctionalizations of alkenes are useful and sophisticated reactions leading to a wide range of chiral non-racemic compounds, for example halogenated δ- and γ-lactones. An in-depth understanding of the mechanism of these complex processes, in particular when Lewis-base catalysis is involved, is a key requirement for optimizing the reaction outcome and design. The group of Professor Scott E. Denmark from the University of Illinois at Urbana-Champaign (USA) has recently reported an important contribution which provides further insight and improves design criteria on the process.