• Conceptually New Approach to Ellipticine and the Oxoaporphine Core

    From left: D. V. Horváth, F. Domonyi (copied in), Dr. R. Palkó, Dr. T. Soós, A. Lomoschitz (Hungarian Academy of Sciences, Budapest, Hungary)

     

Conceptually New Approach to Ellipticine and the Oxoaporphine Core

Regioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine: D. V. Horváth, F. Domonyi, R. Palkó, A. Lomoschitz, T. Soós
Synthesis 2018, DOI: 10.1055/s-0037-1609153


The regioexhaustive functionalization strategy, which was originally introduced by Schlosser, was devised to generate structural diversity utilizing an aromatic or heteroaromatic substrate via iterative and selective metalation reactions, followed by the introduction of protective Cl or TMS groups used to ‘site-silence’ these reactive positions. A novel use of the strategy was recently reported by the group of Dr. Tibor Soós at the Hungarian Academy of Sciences (Budapest, Hungary).

  • Conceptually New Approach to Ellipticine and the Oxoaporphine Core

    Synthesis of the oxoaporphine core and ellipticine

     
Dr. Soós said: “Using the regioexhaustive concept, a general and divergent synthetic strategy has been developed toward functionalized isoquinolines. Owing to its simplicity and robustness, I am sure that this approach will find many applications in drug developments and natural product synthesis.”
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