A Synthesis of S,S-DICHED Catalyst for Matteson Homologations
Christoph Hirschhäuser describes a new route for the synthesis of the S,S-DICHED catalyst.
Ambient-Pressure Asymmetric Preparation of S,S-DICHED, a C2-Symmetrical Director for Matteson Reactions: K. Bojaryn, C. Hoffmann, F. R. Struth, C. Hirschhäuser
Synlett 2018, DOI: 10.1055/s-0036-1591530
The Matteson homologation reaction is a very useful and stereocontrolled process allowing the iterative insertion of a stereogenic one-carbon unit across the C–B bond of a chiral boronic ester (for a tutorial on the Matteson reaction see: https://www.youtube.com/watch?v=uNkt1vo8bj8). Dicyclohexylethane-1,2-diol (DICHED) is one of the most effective ‘chiral directors’ used in the boronic ester function. The group of Dr. Christoph Hirschhäuser from the University of Duisburg-Essen (Germany) has recently reported a user-friendly method for preparing DICHED.