From left: Felix-Alexander Litty (first author), Dr. Dennis Schade (University of Dortmund, Germany)
Synthesis of Enantiopure Nδ-Monomethylated L-Arginine and L-Ornithine
Dennis Schade achieved the synthesis of enantiopure Nδ-monomethylated L-arginine and L-ornithine.
An Efficient Synthesis of Optically Pure Nδ-Monomethylated L-Arginine and L-Ornithine: D. Schade and co-workers
Synthesis 2016, DOI: 10.1055/s-0035-1561303
The physiological balance between L-arginine, methylated arginines such as ADMA (asymmetric Nω,Nω-dimethyl-L-arginine), NMMA (Nω-monomethyl-L-arginine), SDMA (symmetric Nω,Nω′-dimethyl-L-arginine) and their hydrolysis product L-ornithine is strictly controlled by enzymes such as arginases and dimethylarginine dimethylaminohydrolase (DDAH). These molecules can act as regulators of nitric oxide in vivo, which is an essential process because dysregulation of the NO modulating system is associated with a number of pathologies. Efficient access to stereopure methylated arginines and ornithines is very important for in-depth studies on these physiological pathways. Recently, Dr. Dennis Schade from the University of Dortmund (Germany) and colleagues at the University of Kiel (Germany) have reported in Synthesis a new efficient entry to the molecules above.