Aldol Reactions of Pentafluorosulfanyl-Acetic Acid Esters with Aldehydes

The aldol reaction is one of the most powerful and reliable C–C bond-forming processes in organic synthesis, and the resulting β-hydroxy carbonyl structural motif is present in many important natural and bioactive compounds. In addition to Mukaiyama’s silicon-based methodology, the boron-mediated variant has also been developed as one of the most powerful tools of modern aldol chemistry. Both silicon- and boron-Mukaiyama’s aldol reactions involve highly diastereo- and enantioselective, and even catalytic, protocols. The group of Professor Günter Haufe, located at the University of Münster (Germany), is active in the development of new synthetic tools for the preparation of fluorinated compounds with the final aim of biomedical applications.

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