Chemoenzymatic Total Synthesis of Platencin

The identification of new antibiotics showing efficacy against the rapidly growing number of drug-resistant bacteria is becoming a worldwide priority in medicine and healthcare. Among the recently identified molecules displaying novel modes of antibacterial action, one of the most promising is platencin. The current work from Professor Martin Banwell’s group at the Australian National University (Canberra, Australia) is an outgrowth of the group’s broader studies on the application of a class of metabolites known as the cis-1,2-dihydrocatechols to the chemical synthesis of biologically active natural products and related compounds.

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