Intermolecular Haloetherification and Haloesterification of Allyl Amides

Asymmetric alkene halogenation is a powerful synthetic transformation that allows for a straightforward functionalization of readily available compounds into valuable chiral, halogenated building blocks. Although isolated reports of enantioselective variants appeared in the literature in the 1990s, the expansion of the scope and robustness of this transformation has only occurred since 2010, when the group of Professor Babak Borhan at Michigan State University (USA) published a report of a highly enantioselective chlorolactonization reaction. Since then, this research area has witnessed dramatic progress with respect to the scope of transformations and mechanistic understanding. Recently, focus has shifted to the more challenging inter-molecular halofunctionalization of alkenes.

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