Stannyl-Lithium: A Facile and Efficient Synthesis

Stannyl-lithium compounds are extremely versatile and useful reagents for the construction of carbon–carbon bonds; however, the available methods for preparing these compounds are affected by a number of important drawbacks such as low yields and competing side reactions, production of toxic by-products, inconvenient and difficult-to-handle reaction conditions, and the need to use large excesses of Sn sources. Recently, the group of Professor Masanobu Uchiyama at The University of Tokyo (Japan) reported a breakthrough method for accessing these reagents, consisting in a highly efficient, practical, polycyclic aromatic hydrocarbon catalyzed synthesis of stannyl-lithium. The resulting stannyl-lithium shows higher reactivity toward various substrates than existing substrates and is stable at ambient temperature for months.

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