Multistep Continuous-Flow Synthesis of (–)-Oseltamivir
Yujiro Hayashi presents a multistep continuous-flow synthesis of (–)-oseltamivir.
Multistep Continuous-Flow Synthesis of (–)-Oseltamivir:
S. Ogasawara, Y. Hayashi
The antiviral Tamiflu® – or (–)-oseltamivir phosphate – is one of the most effective drugs for treating various forms of influenza. A large number of synthetic approaches – more than 60 – have been reported for this compound. Recently, the group of Professor Yujiro Hayashi from Tohoku University (Japan) has published a flow synthesis of (–)-oseltamivir that has the advantage of being very efficient, safe and highly reproducible.
Professor Hayashi said:
“It is a great synthetic challenge to make Tamiflu with three continuous chiral centers in a single flow system of multi-steps, and it is realized with time economy and pot economy.”