• From left: Prof. M. Dominguez, J. Rodríguez-Aguilar, B. Ordóñez, Dr. M. Vidal (Universidad de Santiago de Chile, Chile)

    From left: Prof. M. Dominguez, J. Rodríguez-Aguilar, B. Ordóñez, Dr. M. Vidal (Universidad de Santiago de Chile, Chile)

     

Microwave-Promoted Synthesis of 4-Arylpyrimidines in Water

Moisés Domínguez describes the microwave-promoted synthesis of 4-arylpyrimidines in water.

Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water: J. Rodríguez-Aguilar, B. Ordóñez, M. Vidal, M. C. Rezende, M. Domínguez
SynOpen 2017, 1, 24–28

The use of environmentally friendly solvents and energy- and time-efficient reaction conditions is becoming an imperative requirement in preparative organic synthesis. 4-Aryl-pyrimidines represent an important class of organic compounds and a frequently encountered structural framework in drugs and bioactive molecules. Recently, the group of Professor Moisés Domínguez from the Universidad de Santiago de Chile has described an efficient novel biocompatible methodology for the synthesis of 4-aryl-pyrimidines.

Professor Dominguez said: “Suzuki–Miyaura coupling of easily accessible 4-pyrimidyl tosylates under microwave irradiation in water allows the access to 4-aryl/heteroaryl/alkyl-pyrimidines, constituting a simple and fast option for the synthesis of these important heterocycles.”

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