Novel Oxazole-Containing Amino Acids
Adel Nefzi presents the synthesis and use of novel oxazolyl amino acids.
Synthesis of Novel Oxazolyl Amino Acids and Their Use in the Parallel Synthesis of Disubstituted Oxazole Libraries: S. Murru, R. Bista, A. Nefzi
Synthesis 2018, DOI: 10.1055/s-0036-1589148
Non-proteinogenic amino acids play a fundamental role in drug discovery and chemical biology, being key building blocks in natural compounds as well as in bioactive peptides and mimics. Recently, a group of researchers led by Dr. Adel Nefzi from the Torrey Pines Institute for Molecular Studies (Florida, USA), published an interesting approach to novel oxazole-containing amino acids.
Professor Nefzi said: “Unnatural amino acids are utilized as building blocks and molecular scaffolds in the construction of combinatorial libraries for drug-discovery research. In continuation of our efforts toward the design and synthesis of novel small molecules and heterocyclic peptidomimetics, we developed an orthogonal deprotection strategy of oxazolyl amino acids, prepared from serine methyl ester and amino acids such as aspartic and glutamic acids to prepare a variety of pharmacologically relevant oxazole-based small molecules.”
