Novel Approach to Organo-Phosphinates and Phosphonates
Selective Substitution of POCl3 with Organometallic Reagents: Synthesis of Phosphinates and Phosphonates: B. Verbelen, W. Dehaen, K. Binnemans
Synthesis 2018, DOI: 10.1055/s-0037-1609435
Organo-phosphinates and -phosphonates are useful compounds whose difficult synthesis – especially of the former – has limited their more widespread use in a number of areas, such as therapeutics, flame retardants and fine chemicals. Recently, the group of Professor Koen Binnemans from the KU Leuven (Belgium) has reported a convenient novel approach for these compounds from readily available starting materials.
Professor Binnemans said: “A convenient and versatile methodology has been developed for the synthesis of a broad range of phosphinate or phosphonate derivatives with long alkyl chains. The new one-pot synthesis approaches are more general than the traditional ones and give access to unsymmetrically substituted compounds. These compounds are useful as reagents for solvent extraction of a variety of metals, including rare earths.”
