Novel Entry to Peptides Incorporating Tryptophan and Analogues
Uli Kazmaier discovered a novel route towards peptides incorporating tryptophan and analogues.
A Straightforward Protocol for the Synthesis of Functionalized Tryptophan Peptides via Stille Coupling, Azidation and Photoinduced Nitrene Insertion: L. Junk, U. Kazmaier
Synlett 2016, 27, DOI: 10.1055/s-0035-1561410
Substituted and differently functionalized tryptophan derivatives are frequently encountered in bioactive and natural peptides but their synthesis often represents a synthetic challenge. A novel method for the synthesis of this class of compounds has been recently reported by the group of Professor Uli Kazmaier from the Universität des Saarlandes, Saarbrücken (Germany), relying on a sequence of reactions involving Stille coupling, azidation and photoinduced nitrene insertion.
Professor Kazmaier said: “The direct, stereoselective introduction of (modified) tryptophans into peptides is a valuable tool for the synthesis of natural products and derivatives thereof.”