From left: Prof. M. Nambo (Nagoya University, Japan), Prof. C. M. Crudden (Queen’s University, Canada)
Novel Entry to Tetraarylmethanes
Masakazu Nambo and Cathleen Crudden describe a novel entry to synthesize tetraarylmethanes.
Synthesis of Tetraarylmethanes by the Triflic Acid-Promoted Formal Cross-Dehydrogenative Coupling of Triarylmethanes with Arenes: M. Nambo, J. C.-H. Yim, K. G. Fowler, C. M. Crudden
Synlett 2017, DOI: 10.1055/s-0036-1588563
Tetraarylmethanes are useful and versatile compounds with a wide range of applications. The most widely applied strategies for their synthesis rely on cross-coupling reactions but the preparation of structurally diverse and nonsymmetrical tetraarylmethanes remains challenging.
Recently, a collaboration between the groups of Professor Masakazu Nambo (Nagoya University, Japan) and Professor Cathleen M. Crudden (Queen’s University, Canada) resulted in the successful development of a new synthetic approach to the title compounds, based on the reaction between triarylmethanes and electron-rich arenes and heteroarenes, promoted by catalytic triflic acid and DDQ.