Why Pharmaceutical Substances?

Essential for research

• Full synthetic route for the industrial manufacture of each drug elucidated from the patent literature
• Unique source of reactions that perform on an industrial scale
• Overview of the pharmaceutical industry from a synthetic chemist's perspective
• Insights into a therapeutic area and chemically related substances

Essential for business development

• First determination of the market size and competition for an API - essential for development of new and generic pharmaceuticals
• Source of markets for synthesis intermediates, ingredients and enzymes
• Patent information including approval date and expiration
• Comprehensive coverage of older APIs and substances approved worldwide
• Merger and acquisition tracking ensuring that vendor information is up-to-date in a rapidly changing industry

Essential for teaching

• Capability to search for marketed drugs relating to a structure or reaction
• A rapid overview of a therapeutic area or chemically related substances
• Industrial synthetic routes discerned from complex patent descriptions
• Insights into industrial processes and toxicity issues
• Commercial information such as trade names and vendors/manufacturers for six world markets
• Concise records ideal for hand-outs and quick reference

“I love Kleemann/Engel [Pharmaceutical Substances] because it helps me prepare for classes, in particular on synthetic design. I don't only cover natural products but also multistep drug syntheses in these courses. It's also very useful for introductory classes in organic chemistry to illustrate, for instance, Friedel-Crafts reactions or Mannich reactions with concrete and important examples. Especially the premeds love it when I show an application in a drug synthesis.”

Prof. Dirk Trauner, New York University, New York, USA