A General and Robust Method for the Preparation of (E)- and (Z)-Stereodefined Fully Substituted Enol Tosylates: Promising Cross-Coupling Partners

Yoo Tanabe presents the synthesis a stereodefined fully substituted enol tosylates.

Regio- and stereocontrolled syntheses of (E)- and (Z)-stereodefined all-carbon-substituted olefins are of pivotal importance and highly challenging tasks in organic synthesis. Recent comprehensive reviews address the impressive progress in this area. Strategies based on stereoretentive cross-coupling reactions using (E)- and (Z)-stereodefined ‘not fully’-substituted enol tosylates – which have interesting synthetic applications – are reliable toward this end. The group of Professor Yoo Tanabe at Kwansei Gakuin University (Japan) introduces a general, cost-effective, and robust protocol for the preparation of all-carbon (fully)-substituted acyclic enol tosylate scaffolds as promising stereoretentive cross-coupling partners.

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