SOS Author Spotlight: Philip Harris (Pyrido[1,2-α]indoles)
Latest update to SOS includes synthetic routes to important hetarene systems: pyrido[1,2-α]indoles and aza analogues
The content of Science of Synthesis has recently been supplemented with a series of chapters by Dr. Philip A. Harris (PA, U.S.A) on the major strategies for the preparation of a variety of hetarene structures based on the pyrido[1,2-α]indole motif. The scope covers benzo-fused derivatives, and also extends to separate chapters covering azapyrido[1,2-α]indoles (which feature an additional nitrogen atom as part of the ring system).
Direct links to the individual chapters can be found below:
10.24 Pyrido[1,2-a]indoles and Azapyrido[1,2-a]indoles (Introduction)
10.24.1 Pyrido[1,2-a]indoles and Related Benzo-Fused Ring Systems
10.24.2 Pyrimido[1,2-a]indoles and Related Benzo-Fused Ring Systems
10.24.3 Pyrimido[1,6-a]indoles and Related Benzo-Fused Ring Systems
10.24.4 Pyrazino[1,2-a]indoles and Related Benzo-Fused Ring Systems
10.24.5 Pyridazino[1,6-a]indoles and Related Benzo-Fused Ring Systems
Philip Harris recently completed a 27-year career as a GlaxoSmithKline centered around primarily kinase inhibitor research. He was a member of drug discovery teams that resulted in two current oncology drugs: Votrient (VEGFR inhibitor, renal cancer) and Tafinlar (b-Raf inhibitor, melanoma). Philip is currently a consultant.
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