Arthur Rudolph Hantzsch and the Synthesis of Nitrogen Heterocycles
This Name Reaction Biography sheds light on the role of Arthur R. Hantzsch in nitrogen heterocycles synthesis.
Heterocyclic compounds containing nitrogen in the ring often exhibit useful biological properties, as in the anti-cholesterol drug, atorvastatin, and the dihydropyridine calcium channel blockers such as amlodipine, felodipine and nifedipine. Polypyrroles are intrinsically conducting polymers, which makes them suitable for applications in electronics, as well as molecular biology and medicine. The subject of this Name Reaction Biography is Arthur Rudolph Hantzsch (1857–1935), who discovered methods for the synthesis of highly substituted pyrroles and dihydropyridines, as well as azoles containing two heteroatoms. A recent review has reported the revival of the Hantzsch pyrrole synthesis under ‘unconventional’ conditions, including microwave irradiation and mechanochemistry.
Read the full article Arthur Rudolph Hantzsch (1857–1935) and the Synthesis of Nitrogen Heterocycles