Catalytic Asymmetric Nucleophilic Fluorination Using BF3·Et2O as Fluorine Source and Activating Reagent
Xianxing Jiang describes trifluoroborate etherate as a useful fluorine source in asymmetric nucleophilic fluorinations.
With the growing applications of fluorinated compounds in modern organic chemistry, pharmaceutical sciences, agrochemistry and materials chemistry, the development of innovative strategies for achieving the selective fluorination of organic molecules represents one of the most hectic areas in chemical research. In particular, the construction of stereogenic C–F bondsubstituted centers is a critically important, albeit still challenging, task in fluorine chemistry. Professor Xianxing Jiang from Sun Yatsen University (P. R. of China), who is strongly interested in organofluorine chemistry, reckons that asymmetric fluorinations using nucleophilic fluorine sources are much less developed as compared to electrophilic strategies, due to the unique features of fluorine atoms (such as high oxidation potential, high hydration energy). Professor Jiang and his research group have been interested in hypervalent iodine catalyzed/promoted reactions (such as asymmetric halogenations, oxidative cyclization and oxyaminations) and Lewis acid catalyzed/mediated chemical synthesis.