Catalytic Remote Hydrohalogenation of Internal Alkenes
Guosheng Liu reports on the remote oxidative halogenation of alkenes under palladium catalysis.
Primary alkyl halogens have wide applications in academic and industrial chemical research as a result of their excellent reactivity toward various organic transformations. In terms of access to this key class of compounds, catalytic halogenation of feedstock olefins is most attractive but highly challenging. Alternatively, the halogenation of alkenes generally provides branched alkyl halides, but there is a lack of methods to prepare linear alkyl halides directly from terminal alkenes, let alone from internal alkenes and mixtures of alkene isomers. Very recently, a remote oxidative halogenation of alkenes under palladium catalysis was reported by the research group of Professor Guosheng Liu at Shanghai Institute of Organic Chemistry, CAS (P. R. of China), who demonstrated that both terminal and internal alkenes can be regioselectively converted into primary alkyl halides with high efficiency.
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