Efficient Co-Catalyzed Double Hydroboration of Nitriles: Application to One-Pot Conversion of Nitriles into Aldimines
Andrey Khalimon reports on the Co-catalyzed one-pot conversion of nitriles into aldimines.
The development of new transformations allowing for selective synthesis of amines from readily accessible precursors continuously attracts significant attention from the synthetic chemistry community, since amines play an indispensable role as building blocks for the synthesis of many natural products, biologically active molecules, pharmaceutical compounds, agrochemicals, etc. In this regard, catalytic reduction of readily available simple feedstock molecules, such as nitriles, to amines using abundant first-row transition-metal catalysts represents an attractive alternative to conventional wasteful stoichiometric reduction methods and catalytic reductions with precious metal catalysts. However, examples of such base metal catalytic systems for efficient and selective room-temperature reduction of nitriles to amines are still scarce and generally require rather sophisticated ligands. The research group of Professor Andrey Khalimon at Nazarbayev University (Kazakhstan) is interested in the development of economical and readily available abundant transition-metal pre-catalysts for the reduction of challenging unsaturated molecules and the application of such transformations in the synthesis of more complex organic molecules.