Deacylative Arylation and Alkynylation of Unstrained Ketones
Xiaheng Zhang describes the deacylative functionalization of unstrained ketones.
The majority of organic compounds are comprised of C–H and C–C bonds, which represent the two pivotal units in organic chemistry and whose synthetic modification constitutes a central aspect in organic synthesis. Professor Xiaheng Zhang from Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (P. R. of China) said that “Complementary to altering existing frameworks through late-stage C–H functionalization, the selective C–C bond activation offers unique opportunities for constructing diverse organic molecule backbones. However, it has still been challenging to develop general and practical methods for C–C bond activation.” As the CO group of ketones is an important structural motif in bioactive natural products and pharmaceuticals and also one of the most prevalent and easily accessible functional groups, it serves as an excellent platform for C–C bond activation reactions.
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