Doubly Stereoconvergent Crystallization Enabled by Asymmetric Catalysis
Jeffrey Johnson reports on a crystallization method using asymmetric catalysis.
Tremendous progress continues to be made in the field of asymmetric catalysis, such as the development of new and better catalysts for the efficient construction of carbon–carbon and carbon–heteroatom bonds. Professor Jeffrey Johnson at the University of North Carolina at Chapel Hill (USA) pointed out that reaction design tends to focus on how to maximize kinetic selectivity in the bond-forming step, while considerations around post-reaction processing (e.g. purifications) tend to receive less attention. He mentioned that “The result of this prioritization is that even for highly efficient reactions, significant time and resources must be spent on isolation of the desired product, which limits the potential application on large scale or in other laboratories without the appropriate equipment.” According to Professor Johnson, an ideal purification method is the direct crystallization or purification of the desired product from the crude reaction mixture. A method enabled by asymmetric catalysis is described here.
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