Enantioselective Cu(I)-Catalyzed Borylative Cyclization of Enone-Tethered Cyclohexadienones and Mechanistic Insights
Rambabu Chegondi describes mechanistic insights of the borylative cyclization of enone-tethered cyclohexadienones.
Dr. Rambabu Chegondi’s research group at CSIR-Indian Institute of Chemical Technology (IICT) in Hyderabad (India) focuses on the development of new synthetic strategies with broad applications in organic synthesis. In particular, the design of new enantio- and diastereoselective desymmetrization methods for prochiral-1,3-diones, cyclohexa-2,5-dienones, and other C2-symmetric substrates to access complex molecules with multiple stereogenic centers are major research goals in the group. Dr. Chegondi said that “over the last decade, the enantioselective desymmetrization of prochiral cyclohexadienones has emerged as the most powerful and convenient strategy for the rapid construction of highly functionalized bicyclic frameworks in a single operation.” His research group has also developed enantioselective transition-metal-catalyzed cyclizations of enone-tethered cyclohexadienones.