Ligand-Promoted Cobalt-Catalyzed Radical Hydroamination of Alkenes

Zhan Lu reports a ligand-promoted cobalt-catalyzed Markovnikov-type selective radical hydroamination of alkenes.

Amines and their derivatives are ubiquitous compounds of great value and paramount importance in a number of areas, including agrochemicals, pharmaceuticals and materials. The development of highly efficient and selective methods to introduce amine groups into organic molecules remains therefore a vibrant area of research in organic synthesis. Since the carbon–carbon double bond is one of the most common structural motifs in organic molecules, highly regio- and enantioselective intermolecular hydroamination of alkenes seems an ideal strategy to access chiral amines. According to Zhan Lu from Zhejiang University in Hangzhou (P. R. of China) the most important unsolved problem of the hydroamination reaction is probably the use of aliphatic terminal alkenes without any activating groups or chelating groups as substrates.

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