SYNTHESIS Best Paper Award 2023: Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids Including Totally Substituted Butenolides and Pyrroles
Takaaki Sato provides the background story to this award-winning paper on the chemistry of stemoamide-type alkaloids.
The award-winning article presents the total synthesis and anti-inflammatory activity of stemoamide-type alkaloids including totally substituted butenolides and pyrroles. A collaborative team from Keio University and Toyama Prefectural University (Japan) led by Takaaki Sato have been awarded the SYNTHESIS Best Paper Award 2023 for their detailed synthetic study of the stemoamide class of heterocycles including tricyclic, tetracyclic and pentacyclic frameworks. The paper includes a stereodivergent strategy in the creation of a fully substituted butenolide. A comprehensive investigation that outlines several optimization reactions, careful structure elucidation and discussion, and anti-inflammatory assays, are highlights on this exciting study. This paper was the subject of a previous SYNFORM News announcement and a SYNTHESIS Highlight article (Synform 2022, 12, A202; DOI: 10.1055/s-0040-1720581) wherein the background and research were discussed in more detail.
Read the full article SYNTHESIS Best Paper Award 2023: Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids Including Totally Substituted Butenolides and Pyrroles
