S,O-Ligand Promoted meta-C–H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis
M. Ángeles Fernández-Ibáñez shows the direct synthesis of meta-arylated anisoles by reversing the conventional site-selectivity.
Palladium-catalyzed C–H functionalization reactions have become powerful synthetic tools in organic chemistry. However, most of the reported examples rely on the use of directing groups to increase the reactivity and selectivity of these processes. Only a few examples of efficient Pd-catalyzed C–H functionalization on non-directed arenes have been reported, and the presence of an external ligand is generally required.
The research group of Professor M. Ángeles (Tati) Fernández-Ibáñez at the University of Amsterdam (The Netherlands) has discovered a new type of S,O-ligand, namely thioether carboxylic acid, that can promote a variety of C–H functionalization reactions on non-directed arenes.