Multi-site Programmable Functionalization of Alkenes via Controllable Alkene Isomerization
Wanbin Zhang reports on the multi-site alkene functionalization via controllable isomerization.
The direct and selective functionalization of hydrocarbon chains, including their multi-functionalization, is a fundamental challenge in modern synthetic chemistry. Conventional functionalization of C=C double bonds and C(sp3)–H bonds provides some solutions, but site diversity remains an issue. According to Professor Wanbin Zhang from Shanghai Jiao Tong University (Shanghai, P. R. of China) “the merging of alkene isomerization with (oxidative) functionalization provides an ideal method for remote functionalization, which would provide more opportunities for site diversity.”
The research described in this article provides a new solution for the diverse functionalization of flexible olefins. The Zhang group designed a new catalytic system which controls the reaction sequence between alkene isomerization and oxidative functionalization, thus achieving multi-site programmable functionalization of terminal alkenes (involving the C=C double bond and multiple C(sp3)–H bonds), accompanied by controllable remote alkenylation.