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Copper-Catalyzed Stereoselective Synthesis of 2-Deoxygalactosides

Copper-Catalyzed Stereoselective Synthesis of 2-Deoxygalactosides: Y. Dong, M. Yuma, Y. Mei, N. Jiang, G. Yang, Z. Wang, J. Zhang
Synlett 2020, 31, DOI: 10.1055/s-0040-1707098

 

Deoxyglycosides are common components of a wide range of bioactive natural products and they often display antibiotic, anticancer, or cardiotonic activities. Unlike fully oxygenated glycosides, the lack of substituents at C-2 to direct the nucleophile approach presents an additional synthetic challenge which has attracted the interest of many research groups. Recently, the group of Professor Jianbo Zhang from the East China Normal University (P. R. of China) reported a new approach for the stereoselective synthesis of 2-deoxygalactosides.

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Professor Jianbo Zhang said: ”Our group is interested in developing novel synthetic strategies and green catalysts to suit the unique and formidable requirements of the glycosylation reaction with high control of chemo-, regio-, and stereoselectivity. This atom-economical copper-catalyzed stereoselective synthesis of 2-deoxygalactosides provides a new approach for the synthesis of deoxysugar-containing glycosides and oligosaccharides, which would benefit researches on glycobiology and glycomedicine.”

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