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Novel Synthesis of Benzoxazoles and Benzimidazoles

Sulfur/DABCO Promoted Reductive Coupling/Annulation Cascade Reaction between o-Hydroxy/Amino Nitrobenzenes and Benzaldehydes: M.-H. D. Dang, L. H. T. Nguyen, P. H. Tran
Synthesis 2020, 52, DOI: 10.1055/s-0039-1690823

 

Benzoxazoles and benzimidazoles are important fused nitrogen-containing heterocycles present in a wide range of natural products, pharmaceuticals, and functional materials. Access to these heterocyclic scaffolds through experimentally simple processes, promoted by inexpensive catalysts – such as molecular sulfur and DABCO – and using readily available substrates is a remarkably valuable goal for synthetic chemists, which has been recently achieved by the group of Professor Phuong Hoang Tran from the Vietnam National University (Ho Chi Min City, Vietnam).

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Professor Tran said: “This strategy is capable of providing a wide range of 2-arylbenzoxazoles or 2-arylbenzimidazoles from o-nitrophenols or o-nitroanilines with benzaldehydes, is highly versatile, and has great potential for industrial application.”

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