Pd-Catalyzed Synthesis of N-Allyloxypyrrolidinediones

Palladium-Catalyzed Oxidative Allylic Alkylation of N-Hydroxyimides: N. Ayyagari, S. Kumar Sunnam, M. M. Ahire, M. Yang, K. Ngo, J. D. Belani
Synlett 2020, 31, 8791


N-Hydroxyimides are very important compounds in organic chemistry and have been used for a number of applications, including peptide synthesis as well as radical and electrocatalytic reactions. Recently, the group of Professor Jitendra D. Belani from Thomas Jefferson University (Philadelphia, USA) reported a novel approach to the title compounds, based on an intermolecular palladium-catalyzed allylic O-alkylation of N-hydroxysuccinimides and -phthalimides with allyl arenes in open air.


Professor Belani said: “Our group has successfully examined N-hydroxyimides as nucleophiles in a palladium-catalyzed allylic substitution via C–H activation.”

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