Synthesis of Polycyclic Indolines

Palladium/Norbornene Chemistry in the Synthesis of Polycyclic Indolines with Simple Nitrogen Sources: M. Ghasemi, F. Jafarpour, A. Habibi
Synthesis 2020, 52, DOI: 10.1055/s-0039-1707988


The indoline scaffold is commonly encountered in natural compounds – such as alkaloids – and drug candidates. A number of synthetic routes are available for assembling the indoline structural framework – such as the Buchwald–Hartwig amination – however, efforts towards the development of atom-economical and efficient target-specific methods for the synthesis of indolines continue to attract the interest of organic chemists. Recently, the group of Professor Farnaz Jafarpour from the University of Tehran (Iran) reported a new approach for the preparation of polycyclic indolines.


Professor Jafarpour said: “We have developed the construction of polycyclic N-alkylindolines via amination of an aryl-norbornene-palladacycle as the key intermediate in Pd/NBE chemistry, employing readily available nitrogen sources such as aliphatic amines and ureas without using any additional ligands.”

Get Trial Access to the chemistry journals
Download SYNFORM or read it online