Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery
Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery: N. Long, A. Le Gresley, A. Solomonsz, A. Wozniak, S. Brough, S. P. Wren
SynOpen 2023, 7, 401–407
In drug design, the creation of a new molecule with similar biological properties to the parent bioactive compoundRecently, the group of Dr. Stephen P. Wren from Kingston University (Kingston upon Thames, UK) reported the efficient synthesis of squaric acid monoamides, which are among the most interesting bioisosteres of carboxylic acids.
Dr. Wren said: “This work describes the preparation of functionalized building blocks that could be used by any medicinal chemistry team for the construction of novel drug candidates.”