Nickel-Catalysed Enantioselective Hydrosulfenation of Alkynes

Qing-Wei Zhang and Gang Lu use nickel catalysis in the hydrosulfenation of alkynes.

Chiral sulfur compounds – such as sulfoxides and sulfoximines – have broad applications in various areas of chemistry, especially at the interfaces with biology, drug discovery and materials science. Often, molecules with different stereochemistry at the sulfur atom exhibit dramatically different chemical and biological properties, which renders critically important the capacity of synthesizing these molecules in a stereocontrolled and stereospecific manner. Professor Qing-Wei Zhang from the University of Science and Technology of China (Hefei, P. R. of China) explained that, as a continuation of his group’s research on the catalytic asymmetric synthesis of P-stereogenic compounds, they expanded their synthetic strategy to include the synthesis of other coordinating elements. For this project they worked in collaboration with the group of Professor Gang Lu from Shandong University (P. R. of China).

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