N-Heterocyclic Carbene- and Organic Photoredox-Catalysed meta-Selective Acylation of Electron-Rich Arenes
Hirohisa Ohmiya reports on the meta-selective acylation of electron-rich arenes.
The Friedel–Crafts reaction serves as a highly useful chemical process, featured prominently in organic chemistry literature and textbooks. Since the initial report from Friedel and Crafts on the acylation of aromatic rings in 1877 this methodology has found widespread applications, extending seamlessly from the laboratory to industrial level, for the synthesis of materials, natural products, and pharmaceutical agents. According to Professor Hirohisa Ohmiya (Kyoto University, Japan), the Friedel–Crafts acylation reaction, specifically, demonstrates high efficiency in the case of electron-rich arenes, which is achieved through the induction of acylium cations. The highlighted paper by his group describes the N-heterocyclic carbene (NHC) and organic photoredox cooperative catalytic meta-selective acylation of electron-rich arenes.
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