Photosensitized Intermolecular Carboimination of Alkenes through the Persistent Radical Effect

Frank Glorius describes an intermolecular, two‐component vicinal carboimination of alkenes.

Aliphatic amines are amongst the most prevalent functionalities in organic molecules, including natural products, drugs, peptides, bioactive compounds and agrochemicals. Owing to their favorable physical and chemical properties, the introduction of amine functionalities in small molecules can increase their likelihood of success as preclinical candidates. According to Frank Glorius from the Westfälische Wilhelms-Universität Münster (Germany) a powerful strategy to synthesize complex primary amines from accessible feedstocks is therefore even more important, since primary amines are the common precursor for amides as well as for secondary and tertiary amines. Here, they developed a 1,2-carboimination strategy for alkenes, resulting in the concurrent installation of both carbon and nitrogen functionalities on the alkenyl framework.

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