Transition-Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines
Weijie Chen provides a Graphical Review on developments in C–H bond functionalization of cyclic amines.
The development of new synthetic methods to access differently substituted and functionalized cyclic amines is of great importance, because a large number of natural products and pharmaceuticals incorporate cyclic amines as key structural frameworks. Many of them contain single or multiple substituents on the ring at the αposition as well as at positions further away from the nitrogen atom. On the other hand, C–H bond functionalization of azaheterocyclic substrates can be considered as one of the most direct and convenient strategies to access the title compounds.
This timely research topic has been recently covered by a Graphical Review in SynOpen, authored by the group of Dr. Weijie Chen (Tongji University, P. R. of China).
Read the full article Transition-Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines
