Synthesis of the Siderophore Erythrochelin
Shigeki Sano reports the synthesis of the hydroxamate-type siderophore erythrochelin.
Synthesis of Erythrochelin: A Hydroxamate-Type Siderophore from Saccharopolyspora erythraea: M. Nakao, S. Tsuji, S. Kitaike, S. Sano
Synthesis 2016, DOI: 10.1055/s-0035-1560564
Erythrochelin is a natural tetrapeptide whose synthesis and specific optical rotation have been recently described for the first time by the group of Professor Shigeki Sano from Tokushima University (Japan). Key step in the synthesis is a cyclization of the dipeptide precursor to provide the core 2,5-diketopiperazine ring.
Professor Sano commented:
“The first synthesis of erythrochelin, a hydroxamate-type siderophore from Saccharopolyspora erythraea, is described and its metal-chelating ability with not only Fe(III) but also Mg(II) is confirmed based on ESI-MS analysis.”