Synthesis of 1-Monosubstituted 1,2,3-Triazoles
Zhen Chen describes the synthesis of 1-monosubstituted 1,2,3-triazoles from propargyl alcohol.
One-Pot Synthesis of 1-Monosubstituted 1,2,3-Triazoles from Propargyl Alcohol: C. Han, S. Dong, W. Zhang, Z. Chen
Synlett 2018, 29, 673–677
The copper-catalyzed 1,3-dipolar cycloaddition reaction of terminal alkynes and azides (or ‘click’ chemistry) is a very convenient and efficient method for the regioselective construction of 1,4-disubstituted 1,2,3-triazoles. On the other hand, the Huisgen dipolar cycloaddition gives 1,4- and 1,5-disubstituted regioisomers without regioselectivity. However, the synthesis of 1-monosubstituted 1,2,3-triazoles has remained more elusive. Recently, the group of Professor Zhen Chen, from the Kunming University of Science and Technology (P. R. of China), described a one-pot method for the synthesis of the title compounds.
