• Richard van der Haas describes the synthesis and properties of 2-oxa-6-azaspiro[3.3]heptane sulfonate salts.

    From left: Dr. E. Damen, J. A. Dekker, Dr. R. N. S. van der Haas (Mercachem Process Research B.V., Nijmegen, The Netherlands)

     

Synthesis of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

Richard van der Haas describes the synthesis and properties of 2-oxa-6-azaspiro[3.3]heptane sulfonate salts.

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts: R. N. S. van der Haas, J. A. Dekker, J. Hassfeld, A. Hager, P. Fey, P. Rubenbauer, E. Damen
Synthesis 2017, 49, DOI: 10.1055/s-0036-1588733

Highly reactive and strained heterocycles are of great interest as building blocks in synthetic organic chemistry and drug discovery. One such unit that has attracted recent interest is the 2-oxa-6-azaspiro[3.3]heptane unit, which has been proposed as a surrogate for morpholine in drug-like compounds and whose synthesis has been shown to be challenging. Recently, the group of Dr. Richard N. S. van der Haas at the company Mercachem Process Research B.V. (Nijmegen, The Netherlands), in collaboration with a group at Bayer Pharma AG (Wuppertal, Germany), has described a novel approach to the target compound.

  • Richard van der Haas describes the synthesis and properties of 2-oxa-6-azaspiro[3.3]heptane sulfonate salts.

    Synthesis of 2-oxa-6-azaspiro[3.3]heptane sulfonate salts

     

Dr. van der Haas said: “With this well-scalable approach 2-oxa-6-azaspiro[3,3]heptane is finally available as a stable, crystalline, well-defined and more soluble sulfonate salt ready for use in chemical conversions.”

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