• Hideki Yorimitsu presents the synthesis of arylalkynes starting from diaryl sulfoxides.

    Prof. Hideki Yorimitsu (Kyoto University, Japan)

     

Synthesis of Arylalkynes from Diaryl Sulfoxides

Hideki Yorimitsu presents the synthesis of arylalkynes starting from diaryl sulfoxides.

C–S Bond Alkynylation of Diaryl Sulfoxides with Terminal Alkynes by Means of a Palladium–NHC Catalyst: Y. Yoshida, K. Nogi, H. Yorimitsu
Synlett 2017, 28, 2561

Arylalkynes are important structural intermediates in organic chemistry owing to the unique properties of their C–C triple bond, which enables a range of useful synthetic transformations. Although many efforts have been directed towards the development of efficient and versatile protocols for the preparation of arylalkynes, their synthesis continues to attract considerable interest in the organic chemistry community. Recently, the group of Professor Hideki Yorimitsu from Kyoto University (Japan) reported another important option to the toolbox of methods available for accessing arylalkynes.

  • Hideki Yorimitsu presents the synthesis of arylalkynes starting from diaryl sulfoxides.

    Synthesis of arylalkynes

     
Professor Yorimitsu said: “This promising Sonogashira-type alkynylation has become a reality by overcoming the contradiction that an electron-rich Pd–NHC catalyst should cleave rather strong C–S bonds in the presence of potentially catalyst-oxidizing sulfenate anions as the leaving groups.”
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