• Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

    From left: Dr. O. O. Grygorenko, M. Kurkunov, Dr. A. V. Tymtsunik (Enamine Ltd., Taras Shevchenko National University of Kyiv, National Technical University of Ukraine, Ukraine)

     

Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks: O. O. Grygorenko, M. Kurkunov, I. A. Levandovskiy, A. V. Tymtsunik
Synthesis 2018, DOI: 10.1055/s-0037-1609434


Conformationally restricted scaffolds are valuable structural units in drug design and discovery. One interesting option is represented by bicyclic cyclobutane-derived heteroaliphatic templates, which have recently attracted increasing interest in different therapeutic areas. Recently, a team of scientists from the Ukraine reported a practical approach to the title structural templates, which holds promise to enable a facilitated access to a range of bioactive drug candidates incorporating 2-azabicyclo[n.2.0]alkane units.

  • Synthese von 2-Azabicyclo[n.2.0]alkan-abgeleiteten Bausteinen

    Synthesis of 2-azabicyclo[n.2.0]alkane derivatives

     
The authors said: “Our approach to 2-azabicyclo[n.2.0]alkanes is a remarkable demonstration of the powerful synthetic tool, namely, the Strecker reaction–intramolecular nucleophilic cyclization (STRINC) sequence, which is used for the preparation of bicyclic amino acids and diamine derivatives.”
Get Trial Access to the chemistry journals
Download SYNFORM or read it online